trying to install ventoy on internal HD

[mufc]

I have a 750Gb 2.5" drive that plugs into my computer that I would like to install ventoy on. it keeps failing. I though this might work. I could make a copy of a good ventoy USB drive with Macrium Reflect, then install it on the 750GB drive.Then adjust the partition sizes. Is it possible to install on an internal hard Drive that is not USB? I thought from reading that is possible but maybe I am missing something.
Thanks in advance.